Har Gobind Khorana: The Genetic Code Breaker and Nobel Laureate
Har Gobind Khorana: The Genetic Code Breaker and Nobel Laureate
Har Gobind Khorana, an Indian-American biochemist, was a pivotal figure in unraveling the mysteries of the genetic code, the fundamental language of life. His groundbreaking work in the 1960s, conducted in collaboration with his team, elucidated how the sequence of nucleotides in DNA dictates the arrangement of amino acids in proteins.
Key contributions and impact Decoding the Genetic Code:
Chemical Synthesis of DNA and RNA: Khorana was at the forefront of chemically synthesizing DNA and RNA molecules with defined sequences. He developed methods for synthesizing short strands of DNA called oligonucleotides, which are essential tools in modern biotechnology and medicine.
First Synthetic Gene: In a groundbreaking achievement in 1970, Khorana and his team were the first to synthesize a fully functional artificial gene outside of a living organism, according to the MIT School of Science.
Exploring DNA Polymerases:
For his profound contributions to deciphering the genetic code and its function in protein synthesis, Khorana, along with Marshall W. Nirenberg and Robert W. Holley, was awarded the 1968 Nobel Prize in Physiology or Medicine. His work laid the foundation for modern molecular biology and biotechnology, with applications ranging from genetic engineering and gene therapy to the development of genetically modified organisms.
Khorana's career spanned decades and continents, leaving a lasting impact on countless students and researchers through his mentorship and dedication to science. His life and achievements continue to inspire future generations of scientists to explore and unravel the mysteries of the universe.
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Har Gobind Khorana, an Indian-American biochemist, was a pivotal figure in unraveling the mysteries of the genetic code, the fundamental language of life. His groundbreaking work in the 1960s, conducted in collaboration with his team, elucidated how the sequence of nucleotides in DNA dictates the arrangement of amino acids in proteins.
Key contributions and impact Decoding the Genetic Code:
Khorana's meticulous experiments helped establish the codon sequences of RNA that correspond to each amino acid, providing crucial insights into how genetic information encoded in DNA and RNA is expressed through protein synthesis. This work was instrumental in proving the triplet nature of the code, meaning three nucleotides (a codon) correspond to one amino acid.
Chemical Synthesis of DNA and RNA: Khorana was at the forefront of chemically synthesizing DNA and RNA molecules with defined sequences. He developed methods for synthesizing short strands of DNA called oligonucleotides, which are essential tools in modern biotechnology and medicine.
First Synthetic Gene: In a groundbreaking achievement in 1970, Khorana and his team were the first to synthesize a fully functional artificial gene outside of a living organism, according to the MIT School of Science.
Exploring DNA Polymerases:
Khorana's research advanced the understanding of DNA polymerases, enzymes critical for DNA replication and the transmission of genetic information.
Confirmation of Universal Genetic Code: He provided substantial evidence supporting the universality of the genetic code, meaning it is consistent across diverse life forms.
Nobel Prize and lasting legacy
Confirmation of Universal Genetic Code: He provided substantial evidence supporting the universality of the genetic code, meaning it is consistent across diverse life forms.
Nobel Prize and lasting legacy
For his profound contributions to deciphering the genetic code and its function in protein synthesis, Khorana, along with Marshall W. Nirenberg and Robert W. Holley, was awarded the 1968 Nobel Prize in Physiology or Medicine. His work laid the foundation for modern molecular biology and biotechnology, with applications ranging from genetic engineering and gene therapy to the development of genetically modified organisms.
Khorana's career spanned decades and continents, leaving a lasting impact on countless students and researchers through his mentorship and dedication to science. His life and achievements continue to inspire future generations of scientists to explore and unravel the mysteries of the universe.
Nominations Open Now |
indianscientist.in
#researchawards #indianscientist#Researchers
Visit: indianscientist.in/
Contact: indian@indianscientist.in
Nomination Link:indianscientist.in/award-nomination/?ecategory=Awards&rcategory=Awardee
Get Connected Here:==================
Youtube: www.youtube.com/@IndianScientist-r6l/featured
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